Blood Coagulation, in Normal and Hypercholesterolemic Dogs, Unmodified by Chylomicrons*

Summary

Investigations were performed on the effects of chylomicrons on blood coagulation. No clotting occurred when dog thoracic duct chylomicrons were substituted for the platelets used in the measurement of thromboplastin generation time.

Hypercholesterolemic or normal dog serum was incubated for 3 hours with chylomicrons to transfer 40% of the chylomicron phospholipids to serum lipoproteins. These sera also did not decrease thromboplastin generation time.

Thromboplastin generation of plasma and whole blood clotting times of dogs on high fat diets were not different than normal controls.

^** Predoctoral Trainee, United States Public Health Service.

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